Prognostic value of left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy

ABSTRACT. Hypertrophic cardiomyopathy (HCM) is one of the widespread genetically determined diseases myocardium, which accompanied by development diastolic and, subsequently, systolic dysfunction myocardium. The aim our study was to evaluate clinical and instrumental features patients with hypertrophic impaired left ventricular global longitudinal strain (GLS) its prognostic value for cardiovascular events in Ukrainian population cardiomyopathy. Materials methods. data 35 who underwent a comprehensive examination determination absolute on speckle-tracking echocardiography were retrospectively analyzed. divided into two groups: Group I (GLS< 14.5) II (GLS≥ 14.5). Results. A decrease associated longer disease duration (8 (5-11) vs 3 (2-5) years, p=0.003), increasing complaints irregularity heart beat (66.7% 23.5%, p= 0.018) weakness (61.1% p=0.04), increased blood pressure (SBP) (130 (120-140) 110 (100-120) mm Hg, 0.009), absence without signs failure (0 29.4%, p=0.019), an increase IVRT (106.19±28.62 84.57±27.54 ms, p=0.044) greater number extrasystoles (17 (4-69) 2 (0.5-3), p=0.014). According Kaplan-Meier analysis survival relation fatal non-fatal or their combination hospitalization failure, they had significantly worse rates (Log-Rank, p=0.016 p=0.003). Conclusions. poor scores characterized unfavorable prognosis.